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Transporte proteinas.Golgi.
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Aparato Golgi, Cis-trans
It is important that translated proteins are delivered to their specific cellular location.
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To accomplish this, the protein is transferred through a series of membrane structures.
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A principal membrane component is the Golgi apparatus.
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The Golgi apparatus is the sorting organelle of the cell.
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Proteins from the rough endoplasmic reticulum are sent to the Golgi.
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As the proteins move through the Golgi apparatus, they are modified and packaged into vesicles.
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Because the Golgi apparatus receives proteins from one location and targets them for delivery
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to a second location, it is sometimes considered the post office of the cell.
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The Golgi apparatus consists of general components.
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The cis-cisterna nearest the endoplasmic reticulum, or ER, the medial and trans-cisternae,
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and the trans-Golgi network.
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Other key players in this process are the proteins being transported and the enzymes
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that modify them.
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Translated proteins are encapsulated in vesicles in the ER.
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A group of these vesicles fuse, and these fused vesicles form the cis cisterna.
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As the protein moves through the stack, it is modified by resident Golgi enzymes at specific
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locations in the apparatus.
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These modifications are important because they provide the signal that determines the
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final destination of the protein.
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So how does the protein move through the Golgi?
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Movement occurs in waves.
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First, the cis cisterna becomes part of the medial Golgi cisternae.
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Behind it, a new cis cisterna is formed by the fusion of vesicles from the ER.
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Meanwhile, one of the medial cisternae migrates and becomes the new trans cisterna.
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Collectively this process is known as the cismaturation model.
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Proteins are sorted within the transgolgi network.
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Proteins with the same target sequence are destined for delivery to the same location.
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The transgolgi network then buds off into vesicles.
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These vesicles then migrate to their target location.
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These locations include internal organelles such as the lysosome, the digestive organelle
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of the cell.
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The vesicles can also be targeted to the cell membrane, where the targeted protein can be
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released from the cell for delivery elsewhere in the organism.
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- Idioma/s:
- Autor/es:
- Virtual Cell
- Subido por:
- Benito H.
- Licencia:
- Reconocimiento - No comercial - Compartir igual
- Visualizaciones:
- 1471
- Fecha:
- 10 de septiembre de 2010 - 18:18
- Visibilidad:
- Público
- Enlace Relacionado:
- Benito Hernández Giménez
- Centro:
- IES MORATALAZ
- Descripción ampliada:
- Las vesículas formadas en el retículo endoplasmático liso forman, uniendose entre ellas, agregados tubulo-vesiculares, los cuales son transportados hasta la región cis del aparato de Golgi por proteinas motoras guiadas por microtúbulos donde se fusionan con la membrana de éste, vaciando su contenido en el interior del lumen.Una vez dentro, las moléculas son modificadas, marcadas y dirigidas hacia su destino final. El aparato de Golgi tiende a ser mayor y más numeroso en aquellas células que sintetizan y secretan continuamente sustancias, como pueden ser los linfocitos B y las células secretoras de anticuerpos.
- Duración:
- 03′ 27″
- Relación de aspecto:
- 1.31:1
- Resolución:
- 1024x780 píxeles
- Tamaño:
- 17.28 MBytes
